MaVen Researchers Report on their “Heart-on-a-Miniscope”

Predicting cardiovascular drug toxicity is a major challenge, with traditional methods often failing to replicate human heart physiology. MaVen team members Pouria Tirgar, Gil Bub, and Allen Ehrlicher, together with their colleagues, have developed a 3D platform using human cardiac organoids and advanced imaging tools like heart-on-a-chip technology.

This system enables detailed, cost-effective testing of drug effects on heart cells, offering a more accurate and reliable way to assess drug safety.

By testing drugs like dofetilide and quinidine, the study demonstrates the potential to reduce adverse effects and improve drug development.

Their research was published in Small (December 2024). Available at: https://doi.org/10.1002/smll.202409571